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Injection Tips includes information about preparing and injecting FUZEON.


About the Syringe Included With Your FUZEON

The Terumo® SurGuard2™ Safety Syringe is provided with FUZEON. This syringe features a protective green cover that snaps into place over the needle after use.

To download complete, step-by-step instructions for injecting FUZEON using Terumo® SurGuard2™ syringes, read the FUZEON Patient Dosing Guide.

It is important to remember the information found on this website is not intended to replace the advice and guidance of your healthcare provider.


This is not a complete list of all the things to know before taking FUZEON with Terumo Sureguard2 syringes. Please refer to the full FUZEON Instructions for Use for more information.

2 times daily dosing and administration

Plan for 2X Daily Injections:

It’s important you not miss a dose, so planning is key. Before the start of your day:

  • block out two dosing times
  • pack supplies for dosing on the go
  • set a reminder alarm

Tip: always have a carrying case with supplies on the ready for spontaneous moments.

FUZEON® (enfuvirtide) injection locations

Pick Where to Inject:

  • Upper thighs, abdomen, upper arms are the optimal places
  • Rotate injection spots each time to reduce injection site reactions

Tip: Upper arms can be hard to reach. Ask a caregiver to get injection training to help you.

FUZEON® (enfuvirtide) 30 minutes duration

Know the Injection Process:

What to expect: Set aside 30 minutes to prepare, inject and dispose of the syringe.

Prepare Solution: You will inject water into a vial of Fuzeon powder and gently mix. Never shake. Once all powder is fully dissolved and there is no foam or air bubbles, you will draw the solution into the syringe.

Inject: Pick an appropriate injection spot and make sure it is a different spot than the last time you injected. Please read and follow the Instructions for Use before each injection.

Dispose: Use a sharps container for safe disposal of FUZEON syringes and needles. To get a free sharps container, call 1-877 4 FUZEON

FUZEON® (enfuvirtide) side effects

Look Out for Side Effects:

Pay attention to how you are feeling. Serious allergic reactions may occur. Please seek immediate medical attention if you start to experience any serious allergic reaction, including:

  • trouble breathing
  • fever with vomiting and a skin rash
  • blood in your urine
  • swelling of your feet
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What is FUZEON?

FUZEON is a medicine called an HIV (human immunodeficiency virus) fusion inhibitor. FUZEON is always used with other anti-HIV medicines to treat adults and children ages 6 years and older with HIV infection.

FUZEON blocks HIV’s ability to infect healthy CD4 cells. When used with other anti-HIV medicines, FUZEON can reduce the amount of HIV in the blood and increase the number of CD4 cells. This may keep your immune system healthy, so it can help fight infection.

Who should not use FUZEON?

Do not use FUZEON if you are allergic to any of the ingredients in FUZEON.

What are the possible side effects of FUZEON?

Injection Site Reactions (ISRs)

FUZEON causes injection site reactions. Almost all people get injection site reactions with FUZEON. Reactions are usually mild to moderate but occasionally may be severe. Reactions on the skin where FUZEON is injected include:

  • itching
  • swelling
  • redness
  • pain or tenderness
  • hardened skin
  • bumps

These reactions generally happen within the first week of FUZEON treatment and usually happen again as you keep using FUZEON. A reaction at one skin injection site usually lasts for less than 7 days. Injection site reactions may be worse when injections are given again in the same place on the body or when the injection is given deeper than it should be (for example, into the muscle).

If you are worried about the reaction you are having, call your healthcare provider to help you decide if you need medical care. If the injection site reaction you are having is severe, call your healthcare provider right away. If you have an injection site reaction, you can discuss with your healthcare provider ways to help the symptoms.

An injection site can get infected. It is important to follow the FUZEON Injection Instructions that come with your medicine to lower your chances of getting an injection site infection.

Call your healthcare provider right away if there are signs of infection at the injection site such as oozing, increasing heat, swelling, redness or pain.

Injection using Biojector® 2000
Shooting nerve pain and tingling lasting up to 6 months from injecting close to large nerves or near joints, and bruising and/or collections of blood under the skin have been reported with use of the Biojector 2000 needle-free device to inject FUZEON. If you are taking any blood thinners, or have hemophilia or any other bleeding disorder, you may be at higher risk of bruising or bleeding after using the Biojector.

Patients with HIV get bacterial pneumonia more often than patients without HIV. Patients taking FUZEON with other HIV medicines may get bacterial pneumonia more often than patients not receiving FUZEON. It is unclear if this is related to the use of FUZEON. You should contact your healthcare provider right away if you have a cough, fever or trouble breathing. Patients are more likely to get bacterial pneumonia if they had a low number of CD4 cells, increased amount of HIV in the blood, intravenous (injected into the vein) drug use, smoking or had experienced lung disease in the past. It is unclear if pneumonia is related to FUZEON.

Allergic reactions 
FUZEON can cause serious allergic reactions. Symptoms of a serious allergic reaction with FUZEON can include:

  • trouble breathing
  • fever with vomiting and a skin rash
  • blood in your urine
  • swelling of your feet

Call your healthcare provider right away if you get any of these symptoms. Discuss with your healthcare provider if you have previously taken FUZEON and experienced any of these reactions.

Other Side Effects
The following side effects were seen more often in patients using FUZEON with their other anti-HIV medicines than in patients not using FUZEON with their other anti-HIV medicines:

  • pain and numbness in feet or legs
  • loss of sleep
  • depression
  • decreased appetite
  • sinus problems
  • enlarged lymph nodes
  • weight decrease
  • weakness or loss of strength
  • muscle pain
  • constipation
  • pancreas problems

These are not all possible side effects of FUZEON. For more information, ask your healthcare provider or pharmacist. If you have questions about side effects, ask your healthcare provider.

As with other anti-HIV medicines, FUZEON may strengthen the body’s immune response which could uncover hidden infections. Report any new or continuing symptoms to your healthcare provider. Your healthcare provider will tell you what to do and may be able to help you with these side effects.

FUZEON is not a cure for HIV infection or AIDS; FUZEON does not prevent the transmission of HIV. For complete details on FUZEON, please see the Patient Information, or call 1-877-4-FUZEON (1-877-438-9366).