The content in this website is for educational purposes only and is not intended to provide medical advice or replace the medical advice of your doctor or other healthcare provider, who should always be your primary source of information about your health, diagnosis, and treatment.


Please choose from the following categories to view frequently asked questions (FAQs) about FUZEON:

General FUZEON FAQs1

What is FUZEON, and how is it designed to work?

Why is FUZEON an injection?

Who is FUZEON for?

Is FUZEON right for a patient who hasn't been on anti-HIV treatment?

Is resistance testing mandatory?

Who should not take FUZEON?

What results have been seen with FUZEON?

What should I do if I miss a dose of FUZEON?

What should I do if I take too much FUZEON?

Does food affect FUZEON?

What else should I discuss with my doctor about FUZEON?

How should I store FUZEON?

Can I travel with FUZEON?

Does my doctor need to know if I am pregnant or plan to become pregnant pregnant before I take FUZEON?

Site Rections and Hypersensitvity FAQs1

Will I get injection site reactions (ISRs)?

How long will my injection site reaction (ISR) last?

Why might my injection site reaction (ISR) last more than 7 days?

My injection site is itching. What should I do?

What should I do if an injection site reaction (ISR) is warm to the touch?

What should I do if I think my injection site reaction (ISR) is infected?

My injection site reaction (ISR) is painful. What should I do?

Why do I still have a small bump at some of my injection sites—even after the reaction is gone?

What are the hypersensitivity reactions associated with FUZEON?

Are there side effects associated with the Biojector® 2000?

Can patients with HIV get bacterial pneumonia more often than patients without HIV?

Can FUZEON cause serious allergic reactions?

What other side effects have patients reported after taking FUZEON?

FUZEON Preparation FAQs1

How long does it take to reconstitute FUZEON?

Is there a way that I can make FUZEON dissolve faster?

What should I do if I see bubbles, foam, or gel in my vial of FUZEON?

Can I mix FUZEON with my other injectable medications?

Can I mix 2 doses of FUZEON at once and store one for later?

Can reconstituted FUZEON be stored in the syringe in the refrigerator?

My vial of reconstituted FUZEON was mistakenly frozen. Can it still be used?

Can reconstituted FUZEON be safely used immediately after it is removed from refrigeration?

Do I have to put the sterile water in the refrigerator?

My FUZEON has expired. What do I do with it?

Why can't I use the same syringe for preparing and injecting FUZEON?

What should I do if I get bubbles in the big syringe (3 cc) when I draw the sterile water?

What should I do if I get bubbles in the small syringe (1 cc) when I draw FUZEON?

How can I prevent air from getting into the syringes when I draw sterile water and/or FUZEON?

FUZEON Injection FAQs1

Does my weight affect where I inject?

I'm running out of sites to inject. What should I do?

When should I change injection sites?

Why do I have to pinch the skin?

How do I know if I'm injecting at a 45-degree angle?

How should I inject into the abdomen?

How should I inject into the upper thigh?

How do I give an injection into the back of my arm?

What should I do if I accidentally inject FUZEON into a vein or a muscle?

Following the injection, why is the solution dripping from the injection site?

I am taking other injectable medications. Can I inject into the same site as FUZEON?

Why do I need to put used needles in the sharps container when the safety syringe needle is already covered by the plastic safety cap?

How do I dispose of my sharps container?


FUZEON Indication

What is FUZEON?

FUZEON is a medicine called an HIV (human immunodeficiency virus) fusion inhibitor. FUZEON is always used with other anti-HIV medicines to treat adults and children ages 6 - 16 years with HIV infection.

FUZEON blocks HIV's ability to infect healthy CD4 cells. When used with other anti-HIV medicines, FUZEON can reduce the amount of HIV in the blood and increase the number of CD4 cells. This may keep your immune system healthy, so it can help fight infection.

FUZEON Contraindication

FUZEON is contraindicated in patients with known hypersensitivity to FUZEON or any of its components

Important Safety Information

What are the possible side effects of FUZEON?

Injection Site Reactions (ISRs)

FUZEON causes injection site reactions.
Almost all people get injection site reactions with FUZEON. Reactions are usually mild to moderate but occasionally may be severe. Reactions on the skin where FUZEON is injected include:

  • itching
  • swelling
  • redness
  • pain or tenderness
  • hardened skin
  • bumps

These reactions generally happen within the first week of FUZEON treatment and usually happen again as you keep using FUZEON. A reaction at one skin injection site usually lasts for less than 7 days. Injection site reactions may be worse when injections are given again in the same place on the body or when the injection is given deeper than it should be (for example, into the muscle).

If you are worried about the reaction you are having, call your healthcare provider to help you decide if you need medical care. If the injection site reaction you are having is severe, call your healthcare provider right away. If you have an injection site reaction, you can discuss with your healthcare provider ways to help the symptoms.

An injection site can get infected. It is important to follow the FUZEON Injection Instructions that come with your medicine to lower your chances of getting an injection site infection.

Call your healthcare provider right away if there are signs of infection at the injection site such as oozing, increasing heat, swelling, redness or pain.

Injection using Biojector® 2000

Shooting nerve pain and tingling lasting up to 6 months from injecting close to large nerves or near joints, and bruising and/or collections of blood under the skin have been reported with use of the Biojector 2000 needle-free device to inject FUZEON. If you are taking any blood thinners, or have hemophilia or any other bleeding disorder, you may be at higher risk of bruising or bleeding after using the Biojector.


Patients with HIV get bacterial pneumonia more often than patients without HIV. Patients with HIV are more likely to get bacterial pneumonia if they have any of the following: a low number of CD4 cells, increased amount of HIV in the blood, intravenous (injected into the vein) drug use, smoking or had experienced lung disease in the past. Patients taking FUZEON with other HIV medicines may get bacterial pneumonia more often than patients not receiving FUZEON. Three patients in the clinical trials who took FUZEON died of pneumonia.

It is unclear if the increased incidence of pneumonia is related to the use of FUZEON. You should contact your healthcare provider right away if you have a cough, fever or trouble breathing.

Allergic Reactions

FUZEON can cause serious allergic reactions. Symptoms of a serious allergic reaction with FUZEON can include:

  • trouble breathing
  • fever with vomiting and a skin rash
  • blood in your urine
  • swelling of your feet

Call your healthcare provider right away if you get any of these symptoms. Discuss with your healthcare provider if you have previously taken FUZEON and experienced any of these reactions.

Other Side Effects

The following side effects were seen more often in patients using FUZEON with their other anti-HIV medicines than in patients not using FUZEON with their other anti-HIV medicines:

  • diarrhea
  • nausea
  • fatigue
  • pain and numbness in feet or legs
  • loss of sleep
  • depression
  • decreased appetite
  • sinus problems
  • enlarged lymph nodes
  • weight decrease
  • weakness or loss of strength
  • muscle pain
  • constipation
  • pancreas problems

These are not all the side effects of FUZEON. For more information, ask your healthcare provider or pharmacist. If you have questions about side effects, ask your healthcare provider.

As with other anti-HIV medicines, FUZEON may strengthen the body's immune response which could uncover hidden infections. Report any new or continuing symptoms to your healthcare provider. Your healthcare provider will tell you what to do and may be able to help you with these side effects.

FUZEON is not a cure for HIV infection or AIDS, Fuzeon does not prevent the transmission of HIV.  For complete details on FUZEON, please see the Patient Product Information,
or call 1-877-4 FUZEON (1-877-438-9366).

1. Fuzeon [package insert]. South San Francisco, CA: Genentech, Inc.; 2015.